Role of lipids in membrane protein insertion and regulation

Principal investigator: Sinning

We will focus on the regulation of protein function by membrane lipids, and analyse specifically the role of lipid interaction for membrane associated proteins involved in protein targeting and for integral membrane proteins. We use a combination of structural and biochemical techniques including X-ray crystallography, SAXS, HX-MS, and reconstitution, as well as GTPase and substrate binding assays to dissect the specific role of lipid binding on protein structure and function at the molecular level.