Characterization of saposin-dependent microdomains in inner lysosomal membranes of Drosophila

Project leader: Sandhoff/Hoch

 

The selective degradation of intra-lumenal membranes and lipids within lysosomes requires acid hydrolases and sphingolipid activator proteins (saposins), which display specific lipid binding specificities. Mutations in human saposins cause fatal lipid storage diseases. The aim of our project is to investigate the role of the conserved Drosophila saposin orthologue saposin-related in lysosomal lipid degradation, cellular clearance and nutrient sensing.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Responsible: Editor
Latest Revision: 2014-02-25