Publications 2014 - 2015

Anheuser S, Breiden B, Schwarzmann G, and Sandhoff, K (2015)
Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.
J. Lipid Res. 56, 1747-61.

Imle, A., Abraham, L., Tsopoulidis, N., Hoflack, B., Saksela, K. and Fackler, O.T.

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with Exocyst.
mBio, 6: e01309-15

Beutel, O., Roder, F., Birkholz, O., Rickert, C., Steinhoff, H.J., Grzybek, M., Coskun, Ü. and Piehler, J. (2015)

A Two-Dimensional Trap for Ultrasensitive Quantification of Transient Protein Interactions.
ACS Nano DOI: 10.1021/acsnano.5b02696

Luisoni, S., Suomalaine M., Boucke, K., Tanner, L.B., Wenk, M.R., Guan, X. L., Grzybek, M., Coskun, Ü., Greber, U.F. (2015)
Co-option of Membrane Wounding Enables Virus Penetration into Cells
Cell Host & Microbe, 18, 75-85

Zeitler M, Steringer JP, Müller HM, Mayer MP, Nickel W. (2015).
HIV-Tat Forms Phosphoinositide Dependent Membrane Pores Implicated in Unconventional Protein Secretion.
J Biol Chem. 2015 Jul 16. pii: jbc.M115.667097. [Epub ahead of print]

Schifferer, M., Feng, S., Stein, F., Tischer, C., Schultz, C., (2015).
Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane. Bioorg.
Med. Chem. 23, 2862-2867

MacNamara, A., Stein, F., Feng, S., Schultz, C., Saez-Rodriguez, J. (2015).
A single-cell model of PIP3 dynamics using chemical dimerization.
Bioorg. Med. Chem. 23, 2868-2876

Inés Romero-Brey, Carola Berger, Stephanie Kallis, Androniki Kolovou, David Paul, Volker Lohmann, Ralf Bartenschlager (2015).
NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication.
mbio, 2015 in press

Dujardin M, Madan V, Montserret R, Ahuja P, Huvent I, Launay H, Leroy A, Bartenschlager R, Penin F, Lippens G, Hanoulle X. (2015).
A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein is Essential for Hepatitis C Virus RNA Replication.
J Biol Chem. 2015 Jun 17. pii: jbc.M115.644419. [Epub ahead of print]

Paul D, Bartenschlager R, McCormick C. (2015).
The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated.
J Gen Virol. 2015 Mar 4. pii: vir.0.000111. doi: 10.1099/vir.0.000111

Podkalicka J, Biernatowska A, Majkowski M, Grzybek M, Sikorski AF (2015).
MPP1 as a Factor Regulating Phase Separation in Giant Plasma Membrane-Derived Vesicles.
Biophys J, 108, 2201-11

Sezgin, E., Grzybek, G., Gutmann, T., Buhl, T., Dirkx, R., Coskun, Ü., Solimena, M., Simons, K., Levental, I., Schwille, P. (2015).
Adaptive lipid packing and bioactivity in membrane domains.
PLOS ONE, DOI: 10.1371/journal.pone.0123930

Kaszuba, K., Grzybek, M., Orlowski, A., Danne, R., Rog, T., Simons, K., Coskun, Ü. and Vattulainen I. (2015).
N-Glycosylation as determinant of Epidermal Growth Factor Receptor conformation in membranes.
PROC. NAT. ACAD. SCI. USA, 112, 4334-4339

Lenoir, M., Grzybek, M., Majkowski, M., Rajesh, S., Kaur, J., Whittaker, S.M., Coskun, Ü. and Overduin M. (2015).
Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins.
JMB, 427, 966–981

Müller HM, Steringer JP, Wegehingel S, Bleicken S, Münster M, Dimou E, Unger S, Weidmann G, Andreas H, García-Sáez AJ, Wild K, Sinning I, Nickel W. (2015).
Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces.

J Biol Chem. 2015 Apr 3;290(14):8925-37. doi: 10.1074/jbc.M114.622456. Epub 2015 Feb 18.

Steringer JP, Müller HM, Nickel W. (2014).
Unconventional secretion of fibroblast growth factor 2--a novel type of protein translocation across membranes?

J Mol Biol
. 2015 Mar 27;427(6 Pt A):1202-10. doi: 10.1016/j.jmb.2014.07.012. Epub 2014 Jul 19. Review.

Geist MM, Pan X, Bender S, Bartenschlager R, Nickel W, Fackler OT. (2014).
Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef.
J Biol Chem. 2014 May 16;289(20):14030-44. doi: 10.1074/jbc.M114.563528. Epub 2014 Apr 4.

Perini ED, Schaefer R, Stöter M, Kalaidzidis Y, Zerial M. (2014).
Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.
Traffic. 2014 Dec;15(12):1366-89. doi: 10.1111/tra.12232. Epub 2014 Nov 6.

Czogalla, A., Kauer, D.J., Seidel, R., Schwille, P., Petrov, E.P. (2014).
DNA Origami Nanoneedles on Freestanding Lipid Membranes as a Tool To Observe Isotropic–Nematic Transition in Two Dimensions.
Nano Letters, 1, 649-55

Chatel-Chaix L, Bartenschlager R. (2014).
Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web.
J Virol 88(11):5907-11. doi: 10.1128/JVI.03404-13. Review

Lee JY, Acosta EG, Stoeck IK, Long G, Hiet MS, Mueller B, Fackler OT, Kallis S, Bartenschlager R. (2014).
Apolipoprotein e likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins.
J Virol. 88(21):12422-37.doi: 10.1128/JVI.01660-14.

Eberle CA, Zayas M, Stukalov A, Pichlmair A, Alvisi G, Müller AC, Bennett KL, Bartenschlager R, Superti-Furga G. (2014).
The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production.
Virology. 462-463:34-41.

Breiden B, Sandhoff K (2014).
The role of sphingolipid metabolism in cutaneous permeability barrier formation.

Biochim Biophys Acta 1841, 441-452.

Rutkowska, A., Plass, T., Hoffmann, J.-E., Yushchenko, D., Feng, S., Schultz, C. (2014).
Click meets FlAsH: a heterologous chemical cross-linker.
ChemBioChem, 15, 1765-1768

Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E. (2014).
Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms.

J Immunol. 2014 Oct 1;193(7):3257-61. doi: 10.4049/jimmunol.1301886. Epub 2014 Sep 3.

Haller C, Müller B, Fritz JV, Lamas-Murua M, Stolp B, Pujol F, Keppler OT, Fackler OT. (2014).
IV-1 Nef and Vpu are Functionally Redundant Broad-Spectrum Modulators of Cell Surface Receptors Including Tetraspanins.
J Virol. 2014 Oct 1. pii: JVI.02333-14. [Epub ahead of print]

Hoeglinger, D., Nadler, A., Schultz, C. (2014).
General Subjects, Caged lipids as tools for investigating cellular signaling.
Biochim Biophys Acta – 1841, 1085-1096.

Feng, S., Laketa, L., Stein, F., Rutkowska, A., MacNamara, A., Depner, S., Klingmueller, U., Saez-Rodriguez, J., Schultz, C. (2014).
A rapidly reversible chemical dimerizer system to study lipid signalling in living cells.
Angew. Chem. Int. Ed. 53, 6720–6723.

Grzybek M., Gutmann T., Coskun Ü. (2014)
Cell Membrane Nanodomains from Biochemistry to Nanoscopy: Functional role of membrane lipids in EGF receptor dynamics and regulation.
(Eds. Lidke, D. & Cambi A) CRC Press, Taylor & Francis Group, in press.

Czogalla A., Grzybek M., Jones W., Coskun Ü. (2014)
Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids.
BBA Molecular and Cell Biology of Lipids, 1841, pages 1049-1059.

Gerl, M.J., Sachsenheimer, T., Grzybek, M., Coskun Ü., Wieland, F.T., Brügger, B. (2014)
Analysis of Transmembrane Domains and Lipid modified Peptides with MALDI-TOF.
Analytical Chemistry, 86, 3722-3726.

Kuerschner L, Thiele C. (2014)
Multiple bonds for the lipid interest.
Biochim Biophys Acta. 2014 Aug; 1841 (8):1031-7.

Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R. (2014)
Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus-Induced Membranous Replication Factories, Independent of RNA Replication.
Gastroenterology. 2014 Jul 18. pii. S0016-5085(14)00915-9. doi: 10.1053/j.gastro.2014.07.019.
[Epub ahead of print].

Madan V, Paul D, Lohmann V, Bartenschlager R. (2014)
Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation.
Gastroenterology. 2014 May;146(5):1361-72.e1-9. doi: 10.1053/j.gastro.2014.01.055. Epub 2014 Jan 31.

Bharat TA, Malsam J, Hagen WJ, Scheutzow A, Söllner TH, Briggs JA (2014)
SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium-triggered fusion.
EMBO Rep. 2014 Mar;15(3):308-14. doi: 10.1002/embr.201337807. Epub 2014 Feb 3.

Geist MM, Pan X, Bender S, Bartenschlager R, Nickel W,  Fackler OT. (2014)
Heterologous Src homology 4 domains support membrane anchoring and biological actitivity of HIV-1 Nef.
J Biol Chem. 2014 May 16;289(20):14030-44. doi: 10.1074/jbc.M114.563528. [Epub 2014 Apr 4].

Hofmann K, Thiele C, Schött HF, Gaebler A, Schoene M, Kiver Y, Friedrichs S, Lütjohann D, Kuerschner L. (2014)
A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization.
J Lipid Res. 2014 Mar;55(3):583-91.

Parisotto D.,Pfau M., Scheutzow A., Wild K., Mayer MP., Malsam J., Sinning I., Söllner TH. (2014)
An extended helical conformation in domain 3a of the SM protein Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex assembly.
J Biol Chem. 2014 April 4;289(14)9639-50. doi: 10.1074/jbc.M113.514273. Epub 2014 Feb 14.

Niehage C., Stange C., Anitei M. and Hoflack B. (2014)
Liposome-based assays to study membrane-associated protein networks. Methods in Enzymology,
534:223-43. doi: 10.1016/B978-0-12-397926-1.00013-5.

Responsible: Editor
Latest Revision: 2015-09-10